Supply chain network design under the risk of uncertain disruptions

Facility disruptions in the supply chain often lead to catastrophic consequences, although they occur rarely. The low frequency and non-repeatability of disruptive events also make it impossible to estimate the disruption probability accurately. Therefore, we construct an uncertain programming model to design the three-echelon supply chain network with the disruption risk, in which disruptions are considered as uncertain events. Under the constraint of satisfying customer demands, the model optimises the selection of retailers with uncertain disruptions and the assignment of customers and retailers, in order to minimise the expected total cost of network design. In addition, we simplify the proposed model by analysing its properties and further linearise the simplified model. A Lagrangian relaxation algorithm for the linearised model and a genetic algorithm for the simplified model are developed to solve medium-scale problems and large-scale problems, respectively. Finally, we illustrate the effectiveness of proposed models and algorithms through several numerical examples.     

绿色住区参数化优化设计平台的开发进展与展望

绿色住区设计是建设宜居城市和实现节能减排目标的重要手段与方法。文章首先回顾绿色住区参数化优化设计方法及平台概况，在此基础上，重点介绍平面生成、噪声计算、通风计算、可视度计算等新增功能和天空遮挡算法升级，以及广州市的工程应用，最后展望平台研发与应用的未来发展方向。     

Flow Cytometry: From Experimental Design to Its Application in the Diagnosis and Monitoring of Respiratory Diseases

Recent advances in the field of flow cytometry (FCM) have highlighted the importance of incorporating it as a basic analysis tool in laboratories. FCM not only allows the identification of cell subpopulations by detecting the expression of molecules in the cell membrane or cytoplasm, but it can also quantify and identify soluble molecules. The proper functioning of the FCM requires six fundamental systems, from those related to the transport of events to the systems dedicated to the analysis of information. In this review, we have identified the main considerations that every FCM user must know for an optimal antibody panel design, the quality systems that must govern the FCM protocols to guarantee reproducible results in research or clinical laboratories. Finally, we have introduced the current evidence that highlights the relevance of FCM in the investigation and clinical diagnosis of respiratory diseases, establishing important advances in the basic and clinical study of diseases as old as Tuberculosis along with the recent proposals for the monitoring and classification of patients infected with the new SARS-CoV2 virus.     

枞树型核电轮槽精铣刀制造技术优化设计

以枞树型叶根精铣刀为例,阐述了可换硬质合金型线刀体和刀片精铣刀的优化设计、制造工艺、建模及优化设计,进行切削过程加工策略优化和加工过程模拟,设计制造了锥柄专用工装及检测环规、磨削刀片后角专用工装,采用NUMROTO软件编制刀片加工工步。该项目研制的可换刀片精铣刀型线精度完全能达到进口铣刀水平,能满足大部分轮槽与叶根加工对型线精度的要求,可以大幅度节约刀具费用。     

泵站压力管道振动特性分析及减振优化设计

为探究泵站压力管道的不同布置形式对管道振动的影响,选取宁夏盐环定泵站工程二泵站#1压力管道为研究对象,建立基于流固耦合的泵站压力管道水流ALGOR数值模型,并采用DASP振动测试系统获取振动信号对模拟结果进行验证,分析压力管道水流流态对管道振动的激励特征并提出优化设计方案。结果表明,压力管道进水管处、支管总管相接处及总出水管处均有强烈的振动,但进水管的振动较出水总管振动更为强烈;减振优化设计方案中,调整支管距离对降低水流对管道振动的激励效果微弱,增大管径及改变总管走向对其效果较好,其中总管走向在2°～5°之间较佳,不仅能降低管道振动,而且能减少泵站能耗损失。研究结果可为高扬程泵站压力管道的优化设计提供理论依据。     

Synthesis of colloidal nanosilica from waste glass powder as a low cost precursor

Waste glass powder was used as a low cost precursor for production of colloidal nanosilica for the first time. The process includes production of wet silica gel and thermal peptization of the wet gel. Purification of the glass powder and wet gel production were initiated by acid washing. The obtained powder was reacted with sodium hydroxide to produce wet silica gel. Type of the applied acid was examined in one factor at a time route. Temperature of the alkaline step and concentrations of the applied acid and base were investigated using Taguchi design of experiments. After finding the best combination of the investigated factor levels in production of the wet gel, time of the stabilization in thermal peptization was studied. Characterizations of the wet gel and colloidal silica were performed by XRF, DLS, FESEM, TEM, FTIR and N₂ sorption evaluation. Accordingly pure and stable colloidal nanosilica (98.50%) with average particle size of 21.9?nm was produced from the glass powder successfully. Specific surface area of the dried porous optimum sample was 83.63?m²/g.     

Patient involvement in Danish hospital design

This paper examines patient-involvement in the process used to design new hospitals. Denmark is in the midst of a phase of hospital building. This recent experience is studied by means of expert interviews with senior practitioners involved in three projects. Examined thematically, the data covers the structure of the design process, identification and ranking of stakeholders, the methods of user-involvement and approaches to accessibility. The paper adds new insight on an under-studied area, design for hospitals and makes recommendations for a change of approach to user-participation in their design. It highlights the difficulties in applying the methods of user-centred design and Design for All in large projects.     

深水水下管汇的结构设计概述

以南海某油气田的深水水下管汇为例,结合管汇的功能需求、结构组成、结构计算等,对深水水下管汇的结构设计进行了概述。